Advertisement
Effect of a topical gel based on Adelmidrol + Trans-traumatic acid in the treatment of diabetic foot ulcers: an open-label study
Search for other papers by Ilaria Teobaldi in
Current site
Google Scholar
PubMed
Search for other papers by Vincenzo Stoico in
Current site
Google Scholar
PubMed
Search for other papers by Fabrizia Perrone in
Current site
Google Scholar
PubMed
Search for other papers by Alessandro Mantovani in
Current site
Google Scholar
PubMed
Search for other papers by Patrizia Piccagli in
Current site
Google Scholar
PubMed
Search for other papers by Fiorenza Grandi in
Current site
Google Scholar
PubMed
Search for other papers by Barbara Baldo in
Current site
Google Scholar
PubMed
BACKGROUND:Diabetic foot ulceration is a severe complication of diabetes characterized by chronic inflammation and impaired wound healing. This study aims to evaluate the effect of a medical device gel based on Adelmidrol + Trans traumatic acid in the healing process of diabetic foot ulcers. METHODS: Thirty-seven diabetic patients with foot ulcers of mild/moderate grade were treated with the gel applied daily for 4 weeks on the affected area. The following parameters were evaluated at baseline and weekly: a) wound area, measured drawing a map of the ulcer then calculated with Photoshop6 tools, b) clinical appearance of the ulcer, assessed recording the presence/absence of dry/wet necrosis, infection, fibrin, neoepithelium, exudate, redness, granulation tissue. RESULTS: Topical treatment led to progressive healing of diabetic foot ulcers with a significant reduction of the wound area and an improvement in the clinical appearance of the ulcers. No adverse events treatment-related were observed. CONCLUSIONS: The results of this open-label study show the potential benefits of Adelmidrol + Trans traumatic acid topical administration to promote re-epithelialization of diabetic foot ulcers. Further studies need to confirm the observed results.
